T.D. Medical College is situated in the suburban area of Vandanam, 9 km south of the Alappuzha (previously Alleppey) town, facing the NH 47, in Alappuzha district of Kerala State, South India. The initials T.D. stand for Thirumala Devaswom, which in Sanskrit means belonging to the Lord of Thirumala, since this medical college was started in 1963 under the patronage of the T.D. Temple at Anantha Narayana Puram of Alappuzha. Initially the management of the college was done by the Kerala Cultural & Educational Society. It was later brought under a trust called "T.D. Medical College Trust", which was headed by the President of the Thirumala Devaswom. The President of the Thirumala Devaswom was Sri. K Nagendra Prabhu and Secretary Sri. N Venkiteswara Prabhu. The day to day administration of the college was done by the T.D. Medical College Administrative Council. Sri. N. V. Prabhu, Thoppil House, Alappuzha, the Honorary Secretary of this council, was the driving force behind the starting of this medical college. A total of 145 acres of land was purchased at Vandanam, in the coastal belt for the future development of the college campus, to include the hospitals, hostels, residential quarters.
The construction of the building started with the foundation stone laying ceremony by sri. R Sankar, Chief Minister of Kerala on March 06, 1963 and the classes started on August 1963.